I just made my first hotkey in an Alfred Workflow to execute an AppleScript that toggles one setting on/off ("Use all F1, F2, etc. keys as standard function keys") and for a while I was wondering why it doesn't seem to work, until I found this.
So basically now every time I hit the hotkey, nothing changes, since the setting is immediately toggled back because the script is run twice.
Hopefully the bugfix release for this is coming soon.