Same problem here. It's made Alfred pretty much useless... I've had to go back to Spotlight
It started randomly one day with v2.1.1, and I just tried upgrading to v2.2 hoping it would be fixed, but the problem is still there.
Most times I see the same issue as OP - 10 seconds (or more) hang after opening Alfred and typing the first search character. But sometimes Alfred hangs before even showing the search window...
I'm using OSX 10.9.2. 100gb free HD space, 16gb ram. Tried repairing disk permissions, clearing Alfred cache, reindexing. Nothing has solved this so far.
Please help me use Alfred again!
